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KMID : 0894520070110030179
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Development & Reproduction
2007 Volume.11 No. 3 p.179 ~ p.185
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Effects of Estradiol-17β and Nonylphenol on mRNA Expression of Estrogen Receptor-related Receptor β Like 1 and Early Embryogensis in Sea Urchin, Strongylocentrotus nudus
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Jung Yu-jung
Maeng Se-Joeng
Sohn Young-Chang
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Abstract
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The estrogens and estrogenic endocrine disrupting chemicals(EDCs) function through a steroid nuclear receptor-mediated process and subsequently regulate the transcription of mRNA for a number of target proteins. The estrogen receptor-related receptors(ERRs), which are structurally similar to estrogen receptors, are members of orphan nuclear receptor in the nuclear receptor superfamily and their functions are known to be involved in the formation of extra-embryonic ectoderm. To investigate effects of EDCs on early embryogenesis and ERR gene expression in marine invertebrates, we examined morphological changes and the mRNA expression of ERRβ like 1 in sea urchin Strongylocentrotus nudus exposed to estradiol-17β(E₂) or nonylphenol(NP). The E₂ and NP-exposed embryos showed a delayed development compared to control embryos. Furthermore, they showed abnormal embryonic developments at late stages, i.e., blastular, gastrula and plutei stages. The mRNA level of ERRβ like 1 at the gastrula stage was significantly lower in E₂ and NP-exposed embryos than those of control group. These results suggest that NP and E₂ are potent chemicals causing abnormal embryonic development of S. nudus through at least in part down-regulated ERRβ like 1.
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KEYWORD
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Sea urchin, Strongylocentrotus nudus, Embryogenesis, ERR β like 1, Estrogen, Nonylphenol
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